According to a preliminary police investigation, the vehicle was traveling on Audubon Avenue in Washington Heights just before 9:40 p.m.
The driver made a left turn toward West 183rd Street, hit the four pedestrians, and then kept on going.
A 36-year-old woman suffered severe head trauma and is in critical condition at Harlem Hospital.
A 28-year-old woman was also taken to Harlem Hospital with a broken leg.
An 8-year-old boy with neck and back pain and an injured ankle and a 9-year-old boy with abrasions to his forehead were taken to Columbia Presbyterian Hospital.
Police are searching for the driver who was behind the wheel of a gray Mercedes Benz.
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