Pan-Cancer Analysis of Whole Genomes
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Stylised illustration showing a virtual landscape of cancer tumoursn with markers identifying genetic information

A collection of research and related content from the ICGC/TCGA consortium on whole‑genome sequencing and integrative analysis of cancer

Cancer is a disease of the genome, caused by a cell’s acquisition of somatic mutations in key cancer genes. These mutations alter pathways involved in regulating cellular growth and interactions with the tissue environment. Until recently, research on the cancer genome was focused on protein-coding genes, which together account for only 1% of the genome. To address this issue, the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Project performed whole‑genome sequencing and integrative analysis on more than 2,600 primary cancers and their matching normal tissues across 38 distinct tumour types.

Flagship paper

Description of the PCAWG resource of >2,600 whole cancer genomes and their matching normal tissues across 38 tumour types, including data, portals, analysis pipelines and downstream integrative analyses. A full list of authors (pdf 145 kb) is available for download.

Browse the collection

Stylised illustration showing a virtual landscape of cancer tumours with markers identifying genetic information
Nik Spencer/Nature

Browse the PCAWG publications in Nature, Nature Genetics, Nature Biotechnology, Nature Communications and Communications Biology. This dedicated collection compiles the PCAWG data sets, other resources and community-generated content, including News & Views, Comment, and an Editorial.

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