CAMBRIDGE, Mass. — The actress Lori Loughlin is expected to plead guilty on Friday in the college admissions case, a dramatic turnaround after more than a year of maintaining her innocence. If a federal judge accepts her plea, she is anticipated to receive a sentence of two months in prison under an agreement reached with prosecutors.Prosecutors accused Ms. Loughlin, 55, and her husband, Mossimo Giannulli, 56, a fashion designer, of paying a college consultant $500,000 to secure their two daughters’ admissions to the University of Southern California as crew recruits, despite neither girl participating in the sport.Ms. Loughlin and Mr. Giannulli are expected to appear before the judge, Nathaniel M. Gorton of the District of Massachusetts, via videoconference, because of restrictions put in place related to the coronavirus pandemic.Ms. Loughlin, best known for playing Aunt Becky on the 1990s sitcom “Full House,” was one of the highest-profile people ensnared in the sweeping admissions case, in which more than 50 people have been charged and more than 30 have pleaded guilty.The other prominent actress charged in the case, Felicity Huffman, who was accused of paying the same consultant to inflate her daughter’s SAT score, pleaded guilty soon after she was arrested and served 11 days in a minimum-security federal prison camp in the San Francisco Bay Area.Under the deal with prosecutors, Ms. Loughlin is expected to plead guilty to one count of conspiracy to commit wire and mail fraud, and Mr. Giannulli is expected to plead guilty to one count of conspiracy to commit wire and mail fraud and honest services wire and mail fraud. Prosecutors will drop charges of money laundering conspiracy and conspiracy to commit federal programs bribery.If the judge accepts the pleas, Ms. Loughlin will, in addition to serving two months in prison, pay a $150,000 fine and do 100 hours of community service. Mr. Giannulli, who prosecutors say was more involved in the scheme, will serve five months in prison, pay a $250,000 fine and do 250 hours of community service.